2. Academic Validation
  3. Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands

Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands

  • Bioorg Med Chem Lett. 2006 Jun 15;16(12):3233-7. doi: 10.1016/j.bmcl.2006.03.047.
Xuqing Zhang 1,  Xiaojie Li,  George F Allan,  Amy Musto,  Scott G Lundeen,  Zhihua Sui
Affiliations

Affiliation

  • 1 Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Raritan, NJ 08869, USA. [email protected]
PMID: 16603353 DOI: 10.1016/j.bmcl.2006.03.047
Abstract

A novel series of tetracyclic indoles have been designed, synthesized and evaluated as Androgen Receptor (AR) ligands. Studies of structure-activity relationships (SARs) were investigated, which led to some compounds in this series as strong Binders to androgen receptors.

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