2. Academic Validation
  3. Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

  • J Med Chem. 2006 May 4;49(9):2677-80. doi: 10.1021/jm051225t.
Curtis R Chong 1,  David Z Qian,  Fan Pan,  Yongfeng Wei,  Roberto Pili,  David J Sullivan Jr,  Jun O Liu
Affiliations

Affiliation

  • 1 Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
PMID: 16640327 DOI: 10.1021/jm051225t
Abstract

To rapidly discover clinically useful angiogenesis inhibitors, we created and screened a library of existing drugs for inhibition of endothelial cell proliferation. Mycophenolic acid (MPA), an immunosuppressive drug, was found to potently inhibit endothelial cell proliferation in vitro and block tumor-induced angiogenesis in vivo. Using RNA interference, we found that knockdown of one of the two known isoforms of inosine monophosphate dehydrogenase (IMPDH-1) is sufficient to cause endothelial cell cycle arrest.

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