2. Academic Validation
  3. Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

  • J Nat Prod. 2006 Apr;69(4):531-5. doi: 10.1021/np050437q.
Naisheng Bai 1,  Ching-Shu Lai,  Kan He,  Zhu Zhou,  Li Zhang,  Zheng Quan,  Nanqun Zhu,  Qun Yi Zheng,  Min-Hsiung Pan,  Chi-Tang Ho
Affiliations

Affiliation

  • 1 Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA.
PMID: 16643020 DOI: 10.1021/np050437q
Abstract

Three new Sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS Cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing Sesquiterpenes, were modestly active in these assays.

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