2. Academic Validation
  3. Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

  • Bioorg Med Chem Lett. 2006 Jul 15;16(14):3809-12. doi: 10.1016/j.bmcl.2006.04.027.
Orla K Mc Carthy 1,  Alessandro Schipani,  Alex Musso Buendía,  Luis M Ruiz-Perez,  Marcel Kaiser,  Reto Brun,  Dolores González Pacanowska,  Ian H Gilbert
Affiliations

Affiliation

  • 1 Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.
PMID: 16677813 DOI: 10.1016/j.bmcl.2006.04.027
Abstract

Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and Anti-parasitic activity.

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