2. Academic Validation
  3. 3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors

3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors

  • Bioorg Med Chem Lett. 2006 Jul 15;16(14):3789-92. doi: 10.1016/j.bmcl.2006.04.043.
Christopher M McBride 1,  Paul A Renhowe,  Thomas G Gesner,  Johanna M Jansen,  Julie Lin,  Sylvia Ma,  Yasheen Zhou,  Cynthia M Shafer
Affiliations

Affiliation

  • 1 Small Molecule Drug Discovery, Medicinal Chemistry Department, Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608, USA.
PMID: 16678414 DOI: 10.1016/j.bmcl.2006.04.043
Abstract

The 3-benzimidazol-2-yl-1H-indazole scaffold was developed as an alternate scaffold for our receptor tyrosine kinase (RTK) inhibitor program. In exploring the SAR of this series, it was discovered that a subset of these compounds potently inhibit the enzyme c-ABL. The SAR of these compounds is described.

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