2. Academic Validation
  3. Antineoplastic Agents. 554. The manitoba bacterium Streptomyces sp

Antineoplastic Agents. 554. The manitoba bacterium Streptomyces sp

  • J Nat Prod. 2006 May;69(5):804-6. doi: 10.1021/np058087v.
George R Pettit 1,  Jiang Du,  Robin K Pettit,  Linda A Richert,  Fiona Hogan,  Venugopal J R V Mukku,  Michael S Hoard
Affiliations

Affiliation

  • 1 Cancer Research Institute, Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 872404, Tempe, Arizona 85287-2404, USA. [email protected]
PMID: 16724845 DOI: 10.1021/np058087v
Abstract

A Streptomyces sp. isolated from riverbank soil in Manitoba, Canada, was found to contain two Cancer cell growth inhibitories: diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8). The structures were determined by interpretation of data from HRMS, UV, and high-field (400 MHz) NMR experiments. The red-colored diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8) were found to inhibit (0.1-3 microg/mL) growth of a minipanel of human Cancer cell lines and P388 lymphocytic leukemia cells. Diazaanthraquinone 1 was also found to inhibit growth of the bacteria Streptococcus pneumoniae and Neisseria gonorrheae. However, three companion constituents, cyclo-Pro-Leu (5), cyclo-Pro-Phe (6), and cyclo-Pro-Val (7), did not inhibit Cancer cell growth.

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