2. Academic Validation
  3. N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor

N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor

  • Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. doi: 10.1016/j.bmcl.2006.05.051.
M Jonathan Fray 1,  Gerwyn Bish,  Alan D Brown,  Paul V Fish,  Alan Stobie,  Florian Wakenhut,  Gavin A Whitlock
Affiliations

Affiliation

  • 1 Sandwich Chemistry, Pfizer Global Research and Development, Sandwich, UK. [email protected]
PMID: 16750359 DOI: 10.1016/j.bmcl.2006.05.051
Abstract

The synthesis and structure-activity relationships of a novel series of piperazine derivatives as dual inhibitors of serotonin and noradrenaline reuptake is described. Two compounds possessed comparable in vitro profiles to the dual reuptake inhibitor duloxetine.

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