2. Academic Validation
  3. neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities

neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities

  • Phytochemistry. 2006 Jul;67(13):1326-30. doi: 10.1016/j.phytochem.2006.04.024.
Sheng-Jun Dai 1,  Jia-Yi Tao,  Ke Liu,  Yong-Tao Jiang,  Li Shen
Affiliations

Affiliation

  • 1 School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China. [email protected]
PMID: 16769097 DOI: 10.1016/j.phytochem.2006.04.024
Abstract

Three neo-clerodane Diterpenoids, named barbatins A-C (1-3), and the neo-clerodane diterpenoid nicotinyl ester, named scutebarbatine B (4), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic analyses (UV, IR, HRFAB-MS, 1D NMR and 2D NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human Cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC50 values in the range 3.5-8.1 microM.

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