2. Academic Validation
  3. Synthesis and biological activity of amide derivatives of nimbolide

Synthesis and biological activity of amide derivatives of nimbolide

  • Bioorg Med Chem Lett. 2006 Aug 15;16(16):4391-4. doi: 10.1016/j.bmcl.2006.05.105.
B S Sastry 1,  K Suresh Babu,  T Hari Babu,  S Chandrasekhar,  P V Srinivas,  A K Saxena,  J Madhusudana Rao
Affiliations

Affiliation

  • 1 Natural Products Laboratory, Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad.
PMID: 16793266 DOI: 10.1016/j.bmcl.2006.05.105
Abstract

Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human Cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity.

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