2. Academic Validation
  3. Vialinin B, a novel potent inhibitor of TNF-alpha production, isolated from an edible mushroom, Thelephora vialis

Vialinin B, a novel potent inhibitor of TNF-alpha production, isolated from an edible mushroom, Thelephora vialis

  • Bioorg Med Chem Lett. 2006 Oct 15;16(20):5424-6. doi: 10.1016/j.bmcl.2006.07.068.
Chun Xie 1,  Hiroyuki Koshino,  Yasuaki Esumi,  Jun-ichi Onose,  Kunie Yoshikawa,  Naoki Abe
Affiliations

Affiliation

  • 1 Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
PMID: 16901696 DOI: 10.1016/j.bmcl.2006.07.068
Abstract

A novel dibenzofuran compound designated vialinin B was isolated from dry fruiting bodies of an edible mushroom, Thelephora vialis, and potently inhibits TNF-alpha production in RBL-2H3 cells (IC(50)=0.02nM) and is a promising anti-allergic agent.

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