2. Academic Validation
  3. Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp

Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp

  • Bioorg Med Chem Lett. 2006 Oct 15;16(20):5398-402. doi: 10.1016/j.bmcl.2006.07.079.
Sang-Jip Nam 1,  Hyunsil Ko,  Mihee Shin,  Jungyeob Ham,  Jungwook Chin,  Youngshin Kim,  Heeyoung Kim,  Kyoungjin Shin,  Hyukjae Choi,  Heonjoong Kang
Affiliations

Affiliation

  • 1 Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Republic of Korea.
PMID: 16905319 DOI: 10.1016/j.bmcl.2006.07.079
Abstract

Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine Sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.

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