Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5580-3. doi: 10.1016/j.bmcl.2006.08.032.

Ki Hun Park ¹, Yong-Dae Park, Jong-Min Han, Kyung-Ran Im, Byong Won Lee, Il Yun Jeong, Tae-Sook Jeong, Woo Song Lee

Affiliations

Affiliation

1 National Research Laboratory of Lipid Metabolism and Atherosclerosis, Insect Resources Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 3806, Republic of Korea.

PMID: 16919944 DOI: 10.1016/j.bmcl.2006.08.032

Abstract

The catecholic Xanthones and Flavonoids 1-13 were isolated from the root bark of Cudrania tricuspidata. Compounds 1 and 3-8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated Flavonoids 10-12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, Flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.

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