2. Academic Validation
  3. Lanostane triterpenoids from the Sri Lankan basidiomycete Ganoderma applanatum

Lanostane triterpenoids from the Sri Lankan basidiomycete Ganoderma applanatum

  • J Nat Prod. 2006 Aug;69(8):1245-8. doi: 10.1021/np0602214.
E Dilip de Silva 1,  Sonia A van der Sar,  R G Lalith Santha,  Ravi L C Wijesundera,  Anthony L J Cole,  John W Blunt,  Murray H G Munro
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Colombo, P.O. Box 1490, Colombo 3, Sri Lanka. [email protected]
PMID: 16933889 DOI: 10.1021/np0602214
Abstract

Two new lanostane-type triterpenoids, 3alpha,16alpha-dihydroxylanosta-7,9(11),24-trien-21-oic acid (1) and 3alpha,16alpha,26-trihydroxylanosta-7,9(11),24-trien-21-oic acid (2), along with three known lanostanoids, 16alpha-hydroxy-3-oxolanosta-7,9(11),24-trien-21-oic acid (3), 3alpha-carboxyacetoxy-24-methylen-23-oxolanost-8-en-26-oic acid (4), and 3alpha-carboxyacetoxy-24-methyl-23-oxolanost-8-en-26-oic acid (5), have been isolated from the EtOAc extract of the fruiting body of Ganoderma applanatum. The structures of 1, 2, and 3 were determined directly by the interpretation of spectroscopic data, while the structures of 4 and 5 were assigned by comparison of spectroscopic data against literature values.

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