2. Academic Validation
  3. Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum

Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum

  • J Nat Prod. 2006 Sep;69(9):1289-94. doi: 10.1021/np060168j.
Véronique Eparvier 1,  Van Hung Nguyen,  Odile Thoison,  Marie-Thérèse Martin,  Thierry Sévenet,  Françoise Guéritte
Affiliations

Affiliation

  • 1 Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
PMID: 16989521 DOI: 10.1021/np060168j
Abstract

The known plagionicin A (1) and eight new monotetrahydrofuran acetogenins, plagionicins B-D (2-4) and plagioneurins A-E (5-9), were isolated from the leaves of Disepalum plagioneurum by bioassay-guided purification. The structures of the new compounds were elucidated by spectroscopic methods. The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB Cancer cell line, with IC(50) values in the nanomolar range.

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