2. Academic Validation
  3. Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides

Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides

  • Bioorg Med Chem. 2007 Jan 15;15(2):839-46. doi: 10.1016/j.bmc.2006.10.043.
Jagadeeshwar R Rao 1,  Raymond F Schinazi,  Chung K Chu
Affiliations

Affiliation

  • 1 The University of Georgia College of Pharmacy, Athens, GA 30602, USA.
PMID: 17085053 DOI: 10.1016/j.bmc.2006.10.043
Abstract

The enantiomerically pure carbocyclic purine and pyrimidine C-nucleosides 1-4 were synthesized via the key intermediate, 2,3-(isopropylidenedioxy)-4-(trityloxymethyl)-4-cyclopenten-1-ol (5), which was prepared from d-ribose in eight steps. Synthesized compounds were evaluated as potential Antiviral agents against HIV, SARSCoV, Punta Toro, West Nile, and Cowpox viruses. However, only 9-deazaneplanocin A (1) exhibited moderate anti-HIV activity.

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