2. Academic Validation
  3. Synthesis of 2'-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells

Synthesis of 2'-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells

  • Bioorg Med Chem Lett. 2007 Feb 1;17(3):617-20. doi: 10.1016/j.bmcl.2006.11.008.
Der-Zen Liu 1,  Supachok Sinchaikul,  Peddiahgari Vasu Govardhana Reddy,  Meng-Yang Chang,  Shui-Tein Chen
Affiliations

Affiliation

  • 1 Graduate Institute of Biomedical Materials, Taipei Medical University, Taipei 110, Taiwan.
PMID: 17113288 DOI: 10.1016/j.bmcl.2006.11.008
Abstract

A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2'-paclitaxel and methyl 2'-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of Other drugs into cells via glucose transporters (GLUTs) for Cancer therapy.

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