2. Academic Validation
  3. Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides

Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides

  • Eur J Med Chem. 2007 Apr;42(4):487-93. doi: 10.1016/j.ejmech.2006.11.002.
Aihong Kim 1,  Joon Hee Hong
Affiliations

Affiliation

  • 1 College of Pharmacy, Chosun University, Kwangju 501-759, Republic of Korea.
PMID: 17188402 DOI: 10.1016/j.ejmech.2006.11.002
Abstract

A series of novel fluorocyclopropyl nucleosides were synthesized starting from acetol using the Simmons-Smith reaction as a key reaction. All the nucleosides synthesized were assayed against several viruses. Among the compounds synthesized, the uracil analogue 22 showed moderate anti-HCMV activity (10.61 microg/mL, in AD-169).

Figures