2. Academic Validation
  3. Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/Suzuki coupling as the key step

Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/Suzuki coupling as the key step

  • J Org Chem. 2007 Feb 16;72(4):1341-6. doi: 10.1021/jo062228w.
Yuan-Qing Fang 1,  Robert Karisch,  Mark Lautens
Affiliations

Affiliation

  • 1 Davenport Chemistry Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
PMID: 17253753 DOI: 10.1021/jo062228w
Abstract

A family of four potent VEGFR2/KDR/Flk-1 kinase inhibitors containing an indol-2-yl quinolin-2-one structure was utilizing a Pd-catalyzed tandem C-N and C-C coupling sequence.

Figures
Products