2. Academic Validation
  3. Synthesis of novel diaryl ethers and their evaluation as antimitotic agents

Synthesis of novel diaryl ethers and their evaluation as antimitotic agents

  • Bioorg Med Chem Lett. 2007 Mar 15;17(6):1799-802. doi: 10.1016/j.bmcl.2006.12.048.
Jin-Kyung In 1,  Mi-Sung Lee,  Jung-Eun Yang,  Jae-Hwan Kwak,  Heesoon Lee,  Shanthaveerappa K Boovanahalli,  Kyeong Lee,  Soo Jin Kim,  Seung Kee Moon,  Sungsook Lee,  Nam Song Choi,  Soon Kil Ahn,  Jae-Kyung Jung
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea. [email protected]
PMID: 17276056 DOI: 10.1016/j.bmcl.2006.12.048
Abstract

A series of novel diaryl ethers possessing various functional groups were synthesized and evaluated for antiproliferative activity in human myeloid leukemia HL-60 cells. Among the compounds examined, compounds 10, 17, 20, 24, and 33 showed moderate to potent antiproliferative activity. These derivatives were further examined in terms of their abilities to inhibit tubulin polymerization; however, all of the tested compounds were relatively ineffective. The reference compound E7010 with an IC(50) of 0.34 microM exhibited potent antiproliferative activity and significantly inhibited tubulin polymerization in a dose-dependent manner.

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