2. Academic Validation
  3. Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B

Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B

  • Bioorg Med Chem Lett. 2007 Apr 15;17(8):2229-32. doi: 10.1016/j.bmcl.2007.01.100.
Ruslan V Bikbulatov 1,  Feng Yan,  Bryan L Roth,  Jordan K Zjawiony
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA.
PMID: 17303418 DOI: 10.1016/j.bmcl.2007.01.100
Abstract

To study drug-receptor interactions, new thio-derivatives of salvinorin A, an extremely potent natural kappa-opioid receptor (KOR) agonist, were synthesized. Obtained compounds were examined for receptor binding affinity. Analogs with the same configuration at carbon atom C-2 as in natural salvinorin A showed higher affinity to KOR than their corresponding epimers.

Figures