Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives

Bioorg Med Chem Lett. 2007 May 15;17(10):2712-7. doi: 10.1016/j.bmcl.2007.03.002.

Tatsuya Horio ¹, Tomohiro Hamasaki, Toshihiko Inoue, Tatsushi Wakayama, Shinsaku Itou, Haruna Naito, Tetsuo Asaki, Hiroki Hayase, Tomoko Niwa

Affiliations

Affiliation

1 Research Laboratories, Nippon Shinyaku Co. Ltd., 3-14-1 Sakura, Tsukuba, Ibaraki 305-0003, Japan.

PMID: 17376680 DOI: 10.1016/j.bmcl.2007.03.002

Abstract

To investigate why 3-substituted benzamide derivatives show dual inhibition of Abl and Lyn Protein Tyrosine Kinases, we determined their inhibitory activities against Abl and Lyn, carried out molecular modeling, and conducted a structure-activity relationship study with the aid of a newly determined X-ray structure of the Abl/Lyn dual inhibitor INNO-406 (formerly known as NS-187) bound to human Abl. We found that this series of compounds interacted with both kinases in very similar ways, so that they can inhibit both kinases effectively.

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