2. Academic Validation
  3. Scaffold targeting drug-resistant colon cancers

Scaffold targeting drug-resistant colon cancers

  • J Med Chem. 2007 May 3;50(9):1999-2002. doi: 10.1021/jm070088s.
Katerina Otrubova 1,  Kathleen L McGuire,  Shelli R McAlpine
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, 5500 Campanile Road, San Diego State University, San Diego, California 92182-1030, USA.
PMID: 17411027 DOI: 10.1021/jm070088s
Abstract

We have identified five derivatives of the natural product sansalvamide A that are potent against multiple drug-resistant colon Cancer cell lines. These analogs share no structural homology to current colon Cancer drugs, are cytotoxic at levels on par with existing drugs treating Other cancers, and demonstrate selectivity for drug-resistant colon Cancer cell lines over noncancerous cell lines. Thus, we have established sansalvamide A as a privileged structure for treating multiple drug-resistant colon cancers.

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