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  3. Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides

Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides

  • Eur J Med Chem. 2008 Jan;43(1):210-21. doi: 10.1016/j.ejmech.2007.03.012.
Francesca Cateni 1,  Paolo Bonivento,  Giuseppe Procida,  Marina Zacchigna,  Luciana Gabrielli Favretto,  Giuditta Scialino,  Elena Banfi
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Sciences, University of Trieste, P.zle Europa, 1, 34127 Trieste, TS, Italy. [email protected]
PMID: 17499886 DOI: 10.1016/j.ejmech.2007.03.012
Abstract

Monogalactosyl diglycerides with medium to long fatty acid acyl chains, were prepared and examined for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The study of their in vitro antimicrobial activity confirms the significant activity of some monogalactosyl diacylglycerol analogues and establishes for the galactose series that the 1,2-disubstitution and the octanoyl chain are the proper structural features for the maximum activity.

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