2. Academic Validation
  3. Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome

Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome

  • Pacing Clin Electrophysiol. 2007 Jun;30(6):823-5. doi: 10.1111/j.1540-8159.2007.00762.x.
Nikolaos Fragakis 1,  Ilias Iliadis,  Soultana Papanastasiou,  Alexandra Lambrou,  George Katsaris
Affiliations

Affiliation

  • 1 Second Cardiac Department, GH G. Papanikolaou, Thessaloniki, Greece. [email protected]
PMID: 17547624 DOI: 10.1111/j.1540-8159.2007.00762.x
Abstract

We report a case of ST elevation in right precordial leads compatible with type 1 Brugada syndrome following administration of propafenone in a patient with Wolff-Parkinson-White syndrome who was receiving lithium at concentrations within therapeutic levels. The mechanism of the electrocardiogram changes was considered to be caused by the two drugs synergistic Sodium Channel blocking effects.

Figures