2. Academic Validation
  3. Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol

Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol

  • Bioorg Med Chem. 2007 Sep 1;15(17):5866-76. doi: 10.1016/j.bmc.2007.05.064.
Vanessa Faugeroux 1,  Yves Génisson,  Yahya Salma,  Patricia Constant,  Michel Baltas
Affiliations

Affiliation

  • 1 Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, UMR 5068, Université Paul Sabatier, 31062 Toulouse, Cedex 9, France.
PMID: 17566744 DOI: 10.1016/j.bmc.2007.05.064
Abstract

Three (S)-prolinol-derived conformationally restricted analogues of the antitubercular agent ethambutol were prepared and tested against Mycobacterium tuberculosis.

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