2. Academic Validation
  3. Cytotoxic clerodane diterpenoids from fruits of Casearia grewiifolia

Cytotoxic clerodane diterpenoids from fruits of Casearia grewiifolia

  • J Nat Prod. 2007 Jul;70(7):1122-6. doi: 10.1021/np070083y.
Somdej Kanokmedhakul 1,  Kwanjai Kanokmedhakul,  Mongkol Buayairaksa
Affiliations

Affiliation

  • 1 Department of Chemistry, Applied Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. [email protected]
PMID: 17567069 DOI: 10.1021/np070083y
Abstract

Bioactivity-guided fractionation of the ethyl acetate-soluble fraction of a methanol extract of the fruits of Casearia grewiifolia afforded eight new clerodane diterpenes, caseargrewiins E-L (1-8), and a known clerodane diterpene, esculentin B (9). The structures of 1-8 were established on the basis of 1D and 2D NMR spectroscopic data. Most of these compounds exhibited cytotoxicity against three Cancer cell lines with IC50 values in the range 0.15-6.00 microg/mL.

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