2. Academic Validation
  3. Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

  • Bioorg Med Chem Lett. 2007 Aug 15;17(16):4428-31. doi: 10.1016/j.bmcl.2007.06.024.
Franck Amblard 1,  Baskaran Govindarajan,  Benjamin Lefkove,  Kimberly L Rapp,  Mervi Detorio,  Jack L Arbiser,  Raymond F Schinazi
Affiliations

Affiliation

  • 1 Department of Pediatrics and Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA.
PMID: 17587572 DOI: 10.1016/j.bmcl.2007.06.024
Abstract

A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.

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