2. Academic Validation
  3. Mycophenolic acid as a latent agonist of PPARgamma

Mycophenolic acid as a latent agonist of PPARgamma

  • Bioorg Med Chem Lett. 2007 Sep 1;17(17):4767-70. doi: 10.1016/j.bmcl.2007.06.059.
Makoto Ubukata 1,  Hitomi Takamori,  Misaki Ohashi,  Shinya Mitsuhashi,  Kaoru Yamashita,  Tomohisa Asada,  Noriyuki Nakajima,  Nobuyasu Matsuura,  Mie Tsuruga,  Keiko Taki,  Junji Magae
Affiliations

Affiliation

  • 1 Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Sapporo, Japan. [email protected]
PMID: 17618115 DOI: 10.1016/j.bmcl.2007.06.059
Abstract

Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor gamma (PPARgamma).

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