2. Academic Validation
  3. Synthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues

Synthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues

  • Bioorg Med Chem. 2007 Nov 1;15(21):6705-15. doi: 10.1016/j.bmc.2007.08.009.
Atul R Gholap 1,  Kiran S Toti,  Fazal Shirazi,  Ratna Kumari,  Manoj Kumar Bhat,  Mukund V Deshpande,  Kumar V Srinivasan
Affiliations

Affiliation

  • 1 Division of Organic Chemistry; Technology, National Chemical Laboratory, Pune, India.
PMID: 17765545 DOI: 10.1016/j.bmc.2007.08.009
Abstract

A series of 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and various analogues have been synthesized in excellent isolated yields starting from various arylidenemalononitrile and 3-amino-2-cyclohexen-1-one in 1-propanol as solvent at reflux temperature in the absence of any added catalyst. All the synthesized compounds were evaluated for their Antifungal activity. The relationship between functional group variation and biological activity of the evaluated compounds is discussed in the article.

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