2. Academic Validation
  3. Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues

Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues

  • Bioorg Med Chem Lett. 2007 Oct 15;17(20):5624-9. doi: 10.1016/j.bmcl.2007.07.079.
Dani Youssef 1,  Christie E Nichols,  T Stanley Cameron,  Jan Balzarini,  Erik De Clercq,  Amitabh Jha
Affiliations

Affiliation

  • 1 Département des Sciences, Université Sainte-Anne, Church Point, NS, Canada B0W 1M0.
PMID: 17768050 DOI: 10.1016/j.bmcl.2007.07.079
Abstract

A series of novel cyclic analogues of curcumin were synthesized and analyzed for in vitro cytostatic activity. Condensation of 2-acetylcycloalkanones with a variety of aromatic aldehydes resulted in the formation of 2-arylidene-6-(3-arylacryoyl)-cycloalkanone derivatives. A number of these analogues were found to have significant Anticancer activity against representative murine and human Cancer cell lines during in vitro bioassays. This corroborated with in vitro cytostatic activity against a panel of 60 cell lines studied at the National Cancer Institute (USA).

Figures