2. Academic Validation
  3. Silyamandin, a new flavonolignan isolated from milk thistle tinctures

Silyamandin, a new flavonolignan isolated from milk thistle tinctures

  • Planta Med. 2007 Sep;73(11):1214-6. doi: 10.1055/s-2007-981595.
Shawna L MacKinnon 1,  Mark Hodder,  Cheryl Craft,  Joanne Simmons-Boyce
Affiliations

Affiliation

  • 1 National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, Canada. [email protected]
PMID: 17823870 DOI: 10.1055/s-2007-981595
Abstract

Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic acid called silyamandin (1). Incubation of the tincture at 40 degrees C for 3 months resulted in an increase in the level of this compound, as observed in the LC/DAD silymarin profile.

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