2. Academic Validation
  3. Synthesis of novel anilinoquinolines as c-fms inhibitors

Synthesis of novel anilinoquinolines as c-fms inhibitors

  • Bioorg Med Chem Lett. 2007 Nov 15;17(22):6257-60. doi: 10.1016/j.bmcl.2007.09.009.
Terrence L Smalley Jr 1,  Stanley D Chamberlain,  Wendy Y Mills,  David L Musso,  Sab A Randhawa,  John A Ray,  Vicente Samano,  Lloyd Frick
Affiliations

Affiliation

  • 1 GlaxoSmithKline, Inc., Five Moore Drive, Research Triangle Park, NC 27709, USA. [email protected]
PMID: 17870531 DOI: 10.1016/j.bmcl.2007.09.009
Abstract

A novel series of potent substituted anilinoquinolines were discovered as c-Fms inhibitors. The potency could be manipulated upon modification of the C4 aniline and C7 aryl functionality. Pharmacokinetic analysis identified a metabolically stable analog suitable for further investigative work.

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