2. Academic Validation
  3. Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

  • Bioorg Med Chem Lett. 2007 Nov 15;17(22):6274-9. doi: 10.1016/j.bmcl.2007.09.012.
George P Lahm 1,  Thomas M Stevenson,  Thomas P Selby,  John H Freudenberger,  Daniel Cordova,  Lindsey Flexner,  Cheryl A Bellin,  Christine M Dubas,  Ben K Smith,  Kenneth A Hughes,  J Gary Hollingshaus,  Christopher E Clark,  Eric A Benner
Affiliations

Affiliation

  • 1 DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. [email protected]
PMID: 17884492 DOI: 10.1016/j.bmcl.2007.09.012
Abstract

Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented.

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