2. Academic Validation
  3. The discovery of indole-derived long acting beta2-adrenoceptor agonists for the treatment of asthma and COPD

The discovery of indole-derived long acting beta2-adrenoceptor agonists for the treatment of asthma and COPD

  • Bioorg Med Chem Lett. 2007 Nov 15;17(22):6188-91. doi: 10.1016/j.bmcl.2007.09.031.
Alan D Brown 1,  Mark E Bunnage,  Paul A Glossop,  Mark Holbrook,  Rhys D Jones,  Charlotte A L Lane,  Russell A Lewthwaite,  Simon Mantell,  Christelle Perros-Huguet,  David A Price,  Rob Webster
Affiliations

Affiliation

  • 1 Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent, UK.
PMID: 17897826 DOI: 10.1016/j.bmcl.2007.09.031
Abstract

The design and profile of a series of indole containing long acting beta(2)-adrenoceptor agonists is described. Evaluation of these analogues using an in vitro guinea pig trachea tissue model demonstrates that analogues within this series have salmeterol-like duration of action with potential for long duration of action in humans.

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