2. Academic Validation
  3. New cytotoxic beta-carboline alkaloids from the marine bryozoan, Cribricellina cribraria

New cytotoxic beta-carboline alkaloids from the marine bryozoan, Cribricellina cribraria

  • J Nat Prod. 1991 Jul-Aug;54(4):1068-76. doi: 10.1021/np50076a023.
M R Prinsep 1,  J W Blunt,  M H Munro
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
PMID: 1791472 DOI: 10.1021/np50076a023
Abstract

Bioactivity-directed separations led to the isolation of the new alkaloid, 1-vinyl-8-hydroxy-beta-carboline [1], as the major cytotoxic component of the marine bryozoan Cribricellina cribraria. Another new beta-carboline alkaloid 2 with the novel sulfone structure was isolated, together with a number of known beta-carboline compounds. Cytotoxicity and antimicrobial effects are reported for these compounds and for Other synthesized beta-carbolines.

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