2. Academic Validation
  3. Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions

Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions

  • IUBMB Life. 2007 Nov;59(11):709-16. doi: 10.1080/15216540701694245.
Kavita Vadali 1,  Xinming Cai,  Michael D Schaller
Affiliations

Affiliation

  • 1 Department of Cell & Developmental Biology and Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
PMID: 17968709 DOI: 10.1080/15216540701694245
Abstract

Recent studies using animal models have demonstrated an important role for FAK in the cardiovascular system. In particular, FAK is essential for angiogenesis in the embryo, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice. FAK function at the cellular level is discussed to provide insight into the mechanisms regulating these biological events and the role of FAK in controlling endothelial junctions and responses to mechanical stimulation are discussed.

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