2. Academic Validation
  3. 2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents

2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents

  • Bioorg Med Chem Lett. 2008 Jan 1;18(1):141-6. doi: 10.1016/j.bmcl.2007.10.111.
Saeed Emami 1,  Alireza Foroumadi,  Mehraban Falahati,  Ensieh Lotfali,  Saeed Rajabalian,  Soltan-Ahmed Ebrahimi,  Shirin Farahyar,  Abbas Shafiee
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari 48175, Iran. [email protected]
PMID: 18032039 DOI: 10.1016/j.bmcl.2007.10.111
Abstract

2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro Antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25-32 microg/mL comparable to reference drug fluconazole. The most active compounds were also assessed for their cytotoxicity using MTT colorimetric assay on normal mouse fibroblast (NIH/3T3) cells. The results of Antifungal activity and toxicity tests indicated that these compounds display Antifungal activity at non-cytotoxic concentrations.

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