2. Academic Validation
  3. Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity

Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity

  • J Nat Prod. 2007 Dec;70(12):1915-8. doi: 10.1021/np0703996.
Kyoko Suzuki 1,  Mamoru Okasaka,  Yoshiki Kashiwada,  Yoshihisa Takaishi,  Gisho Honda,  Michiho Ito,  Yoshio Takeda,  Olimjon K Kodzhimatov,  Ozodbek Ashurmetov,  Michiko Sekiya,  Yasumasa Ikeshiro
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan.
PMID: 18052129 DOI: 10.1021/np0703996
Abstract

The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known Sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human Cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant Cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.

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