2. Academic Validation
  3. Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells

Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells

  • Immunity. 2007 Dec;27(6):965-74. doi: 10.1016/j.immuni.2007.10.010.
Elke Pogge von Strandmann 1,  Venkateswara Rao Simhadri,  Bastian von Tresckow,  Stephanie Sasse,  Katrin S Reiners,  Hinrich P Hansen,  Achim Rothe,  Boris Böll,  Vijaya Lakshmi Simhadri,  Peter Borchmann,  Peter J McKinnon,  Michael Hallek,  Andreas Engert
Affiliations

Affiliation

  • 1 Department of Internal Medicine I, University Hospital of Cologne, Kerpener Str. 62, D-50924 Cologne, Germany. [email protected]
PMID: 18055229 DOI: 10.1016/j.immuni.2007.10.010
Abstract

The activity of natural killer (NK) cells is regulated by surface receptors, which direct target cell recognition. NKp30 (Natural Cytotoxicity Receptor 3) induces target Cell Lysis and is also crucial for the interaction with dendritic cells. So far, the cellular ligands for NKp30 have remained elusive. Here we show that the nuclear factor HLA-B-associated transcript 3 (BAT3) was released from tumor cells, bound directly to NKp30, and engaged NKp30 on NK cells. BAT3 triggered NKp30-mediated cytotoxicity and was necessary for tumor rejection in a multiple myeloma model. These data identify BAT3 as a cellular ligand for NKp30. We propose a concept for target cell recognition by NK cells beyond "missing self" and "induced self," mediated through a tumor cell-derived extracellular factor.

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