2. Academic Validation
  3. In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens

In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens

  • Bioorg Med Chem Lett. 2008 Feb 15;18(4):1511-4. doi: 10.1016/j.bmcl.2007.12.052.
Jae Yeon Kim 1,  Hyo Jin Lim,  Jae-Ha Ryu
Affiliations

Affiliation

  • 1 College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-Gil, Yongsan-Gu, Seoul 140-742, Republic of Korea.
PMID: 18178435 DOI: 10.1016/j.bmcl.2007.12.052
Abstract

Four Flavones, 3,4'-O-dimethylquercetin (1), 3,7-O-dimethylquercetin (2), 3-O-methylquercetin (3) and 3,7,4'-O-trimethylquercetin (4) were isolated as the inhibitors of nitric oxide production in activated microglia (IC(50) values: 11.1, 4.2, 3.8, and 25.1 microM, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC(50) values of 1.75 and 0.77 microM, respectively.

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