2. Academic Validation
  3. Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells

Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells

  • Bioorg Med Chem. 2008 Mar 15;16(6):3445-55. doi: 10.1016/j.bmc.2007.03.003.
Ioannis K Kostakis 1,  Nicole Pouli,  Panagiotis Marakos,  Olga Ch Kousidou,  Andreas Roussidis,  George N Tzanakakis,  Nikos K Karamanos
Affiliations

Affiliation

  • 1 Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
PMID: 18296053 DOI: 10.1016/j.bmc.2007.03.003
Abstract

A series of novel aminosubstituted xantheno[1,2-d]imidazole derivatives have been designed and synthesized and their antiproliferative activity has been evaluated against human breast MDA-MB-231 cell line. Among the tested compounds those bearing two basic side chains at 2- and 5-positions exhibited a strong dose-dependent antiproliferative activity. Increase of the size and basicity of the N-alkyl substituent resulted in amplification of the inhibitory activity.

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