2. Academic Validation
  3. Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles

Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles

  • Bioorg Med Chem Lett. 2008 Apr 1;18(7):2455-8. doi: 10.1016/j.bmcl.2008.02.037.
Caroline M Reid 1,  Charles Ebikeme,  Michael P Barrett,  Eva-Maria Patzewitz,  Sylke Müller,  David J Robins,  Andrew Sutherland
Affiliations

Affiliation

  • 1 WestCHEM, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
PMID: 18313921 DOI: 10.1016/j.bmcl.2008.02.037
Abstract

A focused library of C2-substituted-1,4,7,10-tetraazacyclododecanes was synthesised and the compounds were tested for their ability to kill trypanosome and malaria parasites. Several compounds showed significant in vitro activity and were selectively active against the parasites over human embryonic kidney cells used as a counter screen.

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