2. Academic Validation
  3. Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line

Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line

  • Eur J Med Chem. 2009 Mar;44(3):1355-62. doi: 10.1016/j.ejmech.2008.01.012.
Vijay Virsodia 1,  Atul Manvar,  Kuldip Upadhyay,  Rajesh Loriya,  Denish Karia,  Manu Jaggi,  Anu Singh,  Rama Mukherjee,  Mushtaque S Shaikh,  Evans C Coutinho,  Anamik Shah
Affiliations

Affiliation

  • 1 Jubilant Organosys, 1A, Sector 16-A, Noida 201 301, Uttar Pradesh, India.
PMID: 18316139 DOI: 10.1016/j.ejmech.2008.01.012
Abstract

A small library of 2-indolinone derivatives with the 2,6-dichlorophenyl ring at the N(1) position and with varying substitutions including aryl groups at the 3-position were synthesized, and their structures were confirmed by spectral analysis. All molecules were screened for their in vitro cytotoxic activity on SW620 colon Cancer cell lines. Among the designed series compounds 4c, 4f and 4j were found to be active at concentrations of 2-15 microg/ml. Some 3D-QSAR models were also built to understand the structure-activity relationship.

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