2. Academic Validation
  3. Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds

Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds

  • Bioorg Med Chem. 2008 Apr 15;16(8):4733-41. doi: 10.1016/j.bmc.2008.02.026.
Cyrille Tomassi 1,  Albert Nguyen Van Nhien,  José Marco-Contelles,  Jan Balzarini,  Christophe Pannecouque,  Erik De Clercq,  Denis Postel
Affiliations

Affiliation

  • 1 Laboratoire des Glucides (UMR6219), Faculté des Sciences, Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France.
PMID: 18316194 DOI: 10.1016/j.bmc.2008.02.026
Abstract

Aza TSAO-T derivatives bearing a substituted dihydroisothiazole dioxide ring with a phenyl group at 5'' position were prepared. Biological evaluation showed that phenyl group gives rise to a dramatical decrease of the inhibitory effect.

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