2. Academic Validation
  3. Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound

Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound

  • Bioorg Med Chem Lett. 2008 Apr 1;18(7):2277-81. doi: 10.1016/j.bmcl.2008.03.010.
Cyrille Tomassi 1,  Van Nhien Albert Nguyen,  José Marco-Contelles,  Jan Balzarini,  Christophe Pannecouque,  Erik De Clercq,  Elena Soriano,  Denis Postel
Affiliations

Affiliation

  • 1 Laboratoire des Glucides (UMR6219), Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France.
PMID: 18353641 DOI: 10.1016/j.bmcl.2008.03.010
Abstract

The synthesis and the biological evaluation of the anti-HIV-1 activity of TSAO-Boc(3)T (8) are described. The computational analysis showed that the N-3 Boc group promotes new interactions in the binding site of the enzyme leading to a good inhibitory activity.

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