2. Academic Validation
  3. SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity

SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity

  • Biochem Biophys Res Commun. 2008 May 23;370(1):195-9. doi: 10.1016/j.bbrc.2008.03.075.
Tadanori Yamochi 1,  Kei Ohnuma,  Osamu Hosono,  Hirotoshi Tanaka,  Yoshiyuki Kanai,  Chikao Morimoto
Affiliations

Affiliation

  • 1 Department of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
PMID: 18361920 DOI: 10.1016/j.bbrc.2008.03.075
Abstract

We identified human decapping Enzyme 2 (hDCP2) as a binding protein with Ro52, being colocalized in processing bodies (p-bodies). We also showed that the N-terminus and C-terminus of Ro52 bound to hDCP2. Moreover, Ro52 enhanced decapping activity of hDCP2 in a dose-dependent manner. Our data support the novel notion of the association between Ro52 with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation.

Figures