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  3. Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

  • Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4. doi: 10.1016/j.bmcl.2008.03.053.
Yoichi Nakao 1,  Genta Narazaki,  Takuhiro Hoshino,  Satoko Maeda,  Minoru Yoshida,  Hiroshi Maejima,  Jun K Yamashita
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. [email protected]
PMID: 18397826 DOI: 10.1016/j.bmcl.2008.03.053
Abstract

Evaluation of antiangiogenic activity of marine Sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9microM while azumamide A (1) showed only weak inhibition at 19microM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

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