2. Academic Validation
  3. Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors

Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors

  • Bioorg Med Chem Lett. 2008 May 1;18(9):2948-51. doi: 10.1016/j.bmcl.2008.03.066.
Chung-Kyu Ryu 1,  Ra-Young Lee,  Seung-Yon Lee,  Hwa-Jin Chung,  Sang Kook Lee,  Kwang-Hoe Chung
Affiliations

Affiliation

  • 1 College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. [email protected]
PMID: 18400498 DOI: 10.1016/j.bmcl.2008.03.066
Abstract

A series of 2-phenyl-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activity on the PDGF-stimulated proliferation of rat aortic vascular smooth muscle cells. Among the tested compounds, 6-arylthio-5-chloro-2-phenyl-1H-benzo[d]imidazole-4,7-diones exhibited an potent antiproliferative activity.

Figures