2. Academic Validation
  3. Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum

Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum

  • Bioorg Med Chem Lett. 2008 Jul 1;18(13):3741-4. doi: 10.1016/j.bmcl.2008.05.055.
Nicola Antonio Colabufo 1,  Francesco Berardi,  Marialessandra Contino,  Carmela Inglese,  Mauro Niso,  Roberto Perrone
Affiliations

Affiliation

  • 1 Dipartimento Farmacochimico, Università degli Studi di Bari, via Orabona, 4, 70125 Bari, Italy. [email protected]
PMID: 18524592 DOI: 10.1016/j.bmcl.2008.05.055
Abstract

Several reference compounds such as Cyclosporin A, Tamoxifen, Verapamil, and our compound 1, known as P-gp modulators, have been tested for their P-gp modulating activity in isolated organ bath. Compound 1 showed the best result in organ bath experiment (EC(50)=14.7 microM), Cyclosporin A and Tamoxifen displayed EC(50)=25.2 and 39.4 microM, respectively.

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