2. Academic Validation
  3. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites

Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites

  • J Antibiot (Tokyo). 2008 Jun;61(6):372-8. doi: 10.1038/ja.2008.52.
Kazuhiko Otoguro 1,  Aki Ishiyama,  Miyuki Namatame,  Aki Nishihara,  Toshiaki Furusawa,  Rokuro Masuma,  Kazuro Shiomi,  Yoko Takahashi,  Haruki Yamada,  Satoshi Omura
Affiliations

Affiliation

  • 1 Research Center for Tropical Diseases, The Kitasato Institute, Tokyo, Japan. [email protected]
PMID: 18667785 DOI: 10.1038/ja.2008.52
Abstract

More than 400 compounds isolated from soil Microorganisms, and catalogued in the Antibiotic library of the Kitasato Institute for Life Sciences, were screened against African trypanosomes. Ten compounds were found to have selective and potent antitrypanosomal activity in vitro: aureothin, cellocidin, destomycin A, echinomycin, hedamycin, irumamycin, LL-Z 1272beta, O-methylnanaomycin A, venturicidin A and virustomycin A. Results of the in vitro assays using the GUTat 3.1 strain of Trypanosomal brucei brucei and the STIB900 strain of T. b. rhodesiense are presented. Cytotoxicity was determined using a human MRC-5 cell line. This is the first report of antitrypanosomal activities of the 10 microbial metabolites listed above.

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